Method for enhancing secretory function of mesenchymal stem cells and application thereof
AssigneeShandong University
InventorsShidou Zhao, Zijiang Chen, Yingying Qin, Wenlin Jiao
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Abstract
A method for enhancing the secretory function of mesenchymal stem cells and application thereof, belonging to the field of biotechnology. The present invention finds that the secretory function of umbilical cord mesenchymal stem cells (UCMSCs) can be remarkably promoted by pretreating the UCMSCs in vitro using sodium hyaluronate (HA), including increasing the secretion of cytokines such as HGF, SCF, EGF and VEGF, promoting activation of the PI3K-AKT signaling pathway and enhancing the repair of injury.
Claims6
A method of enhancing secretory function of mesenchymal stem cells comprising administering a composition consisting of sodium hyaluronate to the mesenchymal stem cells, wherein:
- the mesenchymal stem cells are human umbilical cord mesenchymal stem cells;
- the concentration of sodium hyaluronate is 0.1-0.3 mg/ml;
- the composition is administered for 3 to 5 days;
- and
- the administration results in promoting the secretion of cytokines from the mesenchymal stem cells.
Dependencies are inferred from the claim text.