Anti-HER2 polypeptides derivatives as new diagnostic molecular probes
AssigneeBracco Imaging S.P.A.
InventorsErika Reitano, Alessandro Maiocchi, Luisa Poggi, Federico Crivellin, Simon Huet, Mathieu Cinier, Olivier Kitten
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Abstract
The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.
Claims20
A polypeptide that specifically binds to Human Epidermal Growth Factor Receptor 2 (HER2), comprising the amino acid sequence of SEQ ID NO:
- 1.
A conjugate comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 1, wherein the polypeptide is linked to an imaging agent.
Dependencies are inferred from the claim text.