Cosmetic tetrapeptide, composition and use

Abstract

The tetrapeptide has the general Formula X-LLAN-Z (SEQ ID NO: 6) wherein at the N-terminal end X is selected from H, —CO—R1, —SO2—R1 or a biotinoyl group, at the C-terminal end Z is selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 are selected from an alkyl, aryl, aralkyl, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to 24 carbon atoms. A preferred peptide is the Pal-LLAN-OH (SEQ ID NO: 7). This tetrapeptide can stimulate the synthesis of molecules constituting the dermal extracellular matrix, in particular collagen 1 and fibrillin 1, and can be used for a cosmetic treatment, in particular anti-aging, anti wrinkle and fine lines, to improve the skin mechanical properties, firmness/tone/elasticity/flexibility, to increase skin density and volume, for a restructuring effect and/or to fight against stretch marks, and skin sagging. The peptide is also adapted to stimulate hair growth.

Dependencies are inferred from the claim text.