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US 12,686,697 B2Granted
Advantageous morphic form of AT-527 hemi-sulfate salt
AssigneeAtea Pharmaceuticals, Inc.
InventorAdel Moussa
Life of this patent
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Abstract
Advantageous isolated morphic Form III of the hemi-sulfate salt of AT-527 that exhibits a faster rate of dissolution over the amorphous form leading to increased bioavailability and thus efficacy for therapeutic administration in a solid dosage form to treat viral indications, as well as processes for its manufacture.
Claims23
A Compound A Form III isolated crystalline morphic form, wherein Compound A is of structure:
- and the morphic form is characterized by an XRPD pattern comprising at least three 2theta values selected from 5.2±0.2°, 7.3±0.2°, 8.9±0.2°, 10.4±0.2° 13.6±0.2°, 14.7±0.2°, 17.0±0.2°, 18.2±0.2°, 19.9±0.2°, and 21.8±0.2°.
Dependencies are inferred from the claim text.