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US 12,686,667 B2Granted
Methods and compositions for gamma-glutamyl cycle modulation
AssigneeCancer Research Technologies Limited
InventorsDavid Rubin, Eyal Rubin
Life of this patent
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Abstract
The present disclosure provides pharmaceutical compositions comprising Gamma-glutamyl cycle inhibitors (GGCI) and certain pharmaceutically acceptable salts thereof, and methods of use.
Claims13
A compound represented by formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R is independently selected from optionally substituted aryl, heteroaryl, para- methoxyphenyl, ortho-hydroxy phenyl, and phenyl;
- R2 is COOH;
- R3 and R4 are each independently selected from methyl, ethyl, and propyl;
- and
- * is independently selected from selenium and tellurium.
3 more elements
A pharmaceutical composition consisting essentially of a stereoisomeric compound represented by formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R is independently selected from optionally substituted aryl, heteroaryl, para- methoxyphenyl, ortho-hydroxy phenyl, and phenyl;
- R2 is COOH;
- R3 and R4 are each independently selected from methyl, ethyl, and propyl;
- and
- * is independently selected from sulfur, selenium and tellurium;
- and a pharmaceutically acceptable excipient, wherein the pharmaceutically acceptable excipient is:
- selected from an antioxidant selected from ascorbic acid and methionine;
- a preservative selected from octadecyldimethylbenzyl ammonium chloride, hexamethonium chloride, benzalkonium chloride, benzethonium chloride, phenol, butyl alcohol, and benzyl alcohol;
- an alkyl paraben selected from methyl paraben and propyl paraben;
- a sugar selected from:
- glucose, mannose, sucrose, mannitol, trehalose, sorbitol, and dextrin;
- or
- a non-ionic surfactant selected from:
- Tween (Polyoxyethylene (20) sorbitan monolaurate), Pluronic (poly (ethylene oxide)-co-(poly (propylene oxide))), and polyethylene glycol.
12 more elements
Dependencies are inferred from the claim text.