Anti-inflammatory carboxamide derivatives

A compound of formula (I):

• or a pharmaceutically acceptable salt, hydrate, or isomer thereof,
• wherein:
• R1 represents halogen;
• —OR4;
• (C1-C10)alkyl;
• or (C1-C10)alkyl substituted with one or more substituents, the same or different, selected from OH, halogen, (C1-C6)alkyl, —O—(C1-C6)alkyl, nitro, cyano, and halogen;
• or, alternatively,
• R1 together with X2 forms an aromatic, saturated or partially saturated known ring, the ring having 5 or 6 members selected from the group consisting of:
• —C(Rx)2—, —CRx—, —N—, —NRx—, S, and O;
• represents a single bond or a double bond;
• R2 represents —OH;
• halogen;
• (C1-C10)alkyl;
• (C1-C10)alkyl substituted with one or more substituents, the same or different, selected from OH, halogen, (C1-C6)alkyl, —O—(C1-C6)alkyl, nitro, cyano, and halogen;
• —S(O)2R4;
• an aromatic known ring system comprising 5 or 6 members selected from —CRa—, and —N—;
• R3 represents —NR5R6, being R5 and R6 the same or different and being selected from —H, (C1-C10)alkyl, (C3-C10)cycloalkyl, and an aromatic known ring system comprising 5 or 6 members selected from —CRb—, and —N—;
• or, alternatively,
• R2 together with R3 form an aromatic, saturated or partially saturated known ring, the ring having 5 or 6 members selected from —C(Ry)2—, —CRy—, —N—, —NRy, —S—, and —O—;
• A is a known ring system having from 1 to 3 rings and comprising from 4 to 14 members, each one of the members being selected from, —C(Rz)2—, —CRz—, —N—, —NR′z—, —S—, —Se—, —SO2, —SeO2, and —O—;
• the rings being saturated, partially unsaturated, or aromatic;
• and being fused or isolated;
• or, alternatively,
• A represents —NRc-A′, wherein
• Rc represents —H or (C1-C10)alkyl, and
• A′ is a known ring system having from 1 to 3 rings and comprising from 4 to 14 members, each one of the members being selected from, —C(Rz)2—, —CRz—, —N—, —NRz—, —S—, —Se—, —SO2, —SeO2, and —O—;
• the rings being saturated, partially unsaturated, or aromatic;
• and being fused or isolated;
• n represents a enter value comprised from 1 to 7;
• X1 and X2 are the same or different and represent C or N atom;
• R4 represents —H;
• (C1-C10) alkyl;
• or (C1-C10) alkyl substituted with one or more substituents, the same or different, selected from OH, halogen, (C1-C6)alkyl, —O—(C1-C5)alkyl, nitro, cyano, and halogen;
• the term “(C3-C10)cycloalkyl” refers to a saturated carbocyclic ring containing from 3 to 10 carbon atoms;
• each one of Ra is independently selected from the group consisting of —H, —OH, halogen, (C1-C6)alkyl, and (C1-C6)alkyl substituted with one or more substituents, the same or different, selected from:
• OH, halogen, (C1-C6)alkyl, —O—(C1-C6)alkyl, nitro, cyano, and halogen;
• each one of Rb is independently selected from the group consisting of —H, —OH, halogen, (C1-C6)alkyl, and (C1-C6)alkyl substituted with one or more substituents, the same or different, selected from:
• OH, halogen, (C1-C6)alkyl, —O—(C1-C6)alkyl, nitro, cyano, and halogen;
• Rt represents (C1-C10) alkyl;
• each one of the Rx is independently selected from the group consisting of —H, —OH, (C1-C6)alkyl, (C1-C6)haloalkyl, —O—(C1-C6)alkyl, nitro, —NR7—, —NR8R9, and halogen;
• each one of the Ry is independently selected from the group consisting of —H, —OH, (C1-C6)alkyl, (C1-C5)haloalkyl, —O—(C1-C6)alkyl, nitro, —NR10—, —NR11R12, and halogen;
• each one of the Rz is independently selected from the group consisting of —H, —OH, (C1-C6)alkyl, (C1-C6)haloalkyl, —O—(C1-C6)alkyl, —O—(C1-C6)haloalkyl, nitro, —NR13—, —NR12R15, and halogen;
• R′z is selected from the group consisting of (C1-C6)alkyl and (C1-C6)haloalkyl;
• and
• each one of R7 to R15 is independently selected from the group consisting of H, (C1-C6)alkyl, (C1-C6)haloalkyl, and —O—(C1-C6)alkyl.