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US 12,686,007 B2Granted
Fluid self-modulation
Assignee1087 Systems, Inc.
InventorMatthias Wagner
Life of this patent
Estimating the term…
Abstract
Combining through self-modulation a flow of active media from a working vessel of a bioprocess together with a flow of reference media and making a time- and/or spatially-resolved referenced optical measurement of the active vs reference media in a confined flow region and time, such that the two liquids are measured in substantially identical conditions.
Claims16
A microfluid flow system comprising:
- a plurality of input ports, each of the plurality of input ports for receiving a liquid;
- a means for applying pressure to each received liquid;
- a liquid merge junction that merges the pressurized liquid from each of the plurality of input ports into a merged liquid flow in a microfluid flow channel;
- an obstruction disposed in the microfluid flow channel that creates a vortex shedding state of the merged liquid as the merged liquid flows past the obstruction;
- an optical interrogation region disposed at an optical sensing position downstream from the obstruction;
- an electromagnetic radiation source that delivers, at the optical interrogation region, electromagnetic radiation at one or more wavelengths relevant to an optical characteristic of the merged liquid;
- a detector that measures a result of the radiation interacting with the merged liquid at the optical interrogation region;
- and
- a computing system that receives an output of the detector and calculates a one or more of physical characteristics or biochemical characteristics of the merged liquid based on the output of the detector.
6 more elements
A microfluid flow system comprising:
- a liquid merge junction that merges a plurality of pressurized liquids into a merged liquid flow of a microfluid flow channel that is configured to create a vortex shedding state of the merged liquid flow;
- an electromagnetic radiation source that delivers electromagnetic radiation to the merged liquid flow in the vortex shedding state at one or more wavelengths relevant to an optical characteristic of the merged liquid flow;
- and
- a computing system that monitors the delivery of the electromagnetic radiation to the merged liquid flow and calculates one or more of physical characteristics or biochemical characteristics of the merged liquid flow based on the monitoring.
1 more element
Dependencies are inferred from the claim text.