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US 12,685,803 B2Granted
Antimicrobial polymer for use in ophthalmic implants
AssigneeKeramed, Inc.
InventorYichieh Shiuey
Life of this patent
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Abstract
An antimicrobial polymer for use in an ophthalmic implant, includes at least one antimicrobial monomer; and at least one other monomer selected from an acrylic, silicone, vinyl and collagen monomer.
Claims4
An ophthalmic implant comprising an antimicrobial polymer comprising:
- at least one antimicrobial monomer is a quaternary ammonium salt-based monomer selected from 1-[12-(methacryloyloxy) dodecyl]pyridinium bromide (MDPB), methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), 2-methacryloxyethyl dodecyl methyl ammonium bromide (MAE-DB), 2-methacryloxyethyl hexadecyl methyl ammonium bromide (MAE-HB) or bis(2-methacryloxyethyl) dimethyl ammonium bromide (IDMA-1);
- and
- monomers selected from hydrophobic acrylic monomers or hydrophilic acrylic monomers,
- wherein the hydrophobic acrylic monomers are selected from monomers of ethyl acrylate, ethyl methacrylate, 2,2,2-trifluoroethyl methacrylate, cross linked with ethylene glycol dimethacrylate, which form a copolymer of ethyl acrylate, ethyl methacrylate, 2,2,2-trifluoroethyl methacrylate, cross linked with ethylene glycol dimethacrylate;
- or monomers of phenylethyl methacrylate and n-butyl acrylate, fluoroalkyl methacrylate, which form a cross linked copolymer of phenylethyl methacrylate and n-butyl acrylate, fluoroalkyl methacrylate;
- and
- wherein the hydrophilic acrylic monomers are selected from monomers of hydroxyethyl methacrylate and methyl methacrylate, which form a copolymer of hydroxyethyl methacrylate and methyl methacrylate;
- monomers of 2-hydroxyethylmethacrylate and 2-ethoxyethylmethacrylate, which form a copolymer of 2-hydroxyethylmethacrylate and 2-ethoxyethylmethacrylate;
- and monomers of 2-hydroxyethylmethacrylate and methyl methacrylate, which form a copolymer of 2-hydroxyethylmethacrylate and methyl methacrylate.
6 more elements
Dependencies are inferred from the claim text.