Regenerative tissue and natural tissue implants
AssigneeVascudyne, Inc.
InventorsRichard F. Murphy, Kemal Schankereli, Mark Lauren
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Abstract
The present invention is an improved implant made from regenerative tissue or natural tissue, methods of making the implant, and methods of using the implant.
Claims8
A prosthesis comprising biologically engineered extracellular matrix (ECM) tissue formed into pre-determined shape, wherein a central portion of said prosthesis is isodiametric, a first end of said prosthesis is flared, and a second end of said prosthesis is a cuff, wherein an internal diameter of said central portion is from 2 mm to 6 mm, or wherein the internal diameter is from 2 mm to 4 mm, or wherein the internal diameter is from 3 mm to 6 mm.
A process for making a prosthesis comprising culturing regenerative extracellular matrix (ECM) tissue, wherein said culturing occurs around a mandrel, shape or form and results in a shaped prosthesis;
- removing the shaped prosthesis from the mandrel, shape, or form;
- and shaping at least one end of said prosthesis, wherein a central portion of said prosthesis is isodiametric, a first end of said prosthesis is flared, and a second end of said prosthesis is a cuff, wherein an internal diameter of said central portion is from 2 mm to 6 mm, or wherein the internal diameter is from 2 mm to 4 mm, or wherein the internal diameter is from 3 mm to 6 mm.
A process for preparing a graft comprising the steps of:
- 1) selecting an animal tissue specimen;
- 2) cleaning the selected tissue to produce a cleaned tissue;
- 3) digesting the cleaned tissue with at least one enzyme to produce digested tissue;
- 4) surface-treating the digested tissue to produce surface-treated tissue;
- 5) forming the surface-treated tissue into a predetermined shape to produce formed tissue, wherein a central portion of said shape is isodiametric, a first end of said shape is flared, and a second end of said shape is a cuff;
- 6) crosslinking the formed tissue to produce crosslinked tissue;
- and 7) sterilizing the crosslinked tissue, wherein an internal diameter of said central portion is from 2 mm to 6 mm, or wherein the internal diameter is from 2 mm to 4 mm, or wherein the internal diameter is from 3 mm to 6 mm.
Dependencies are inferred from the claim text.