Connection system and active sterilizer for a drug delivery device

A method for creating an aseptic connection within a medical injection device, the medical injection device comprising a housing configured to receive a medicament container that is sealed with a medicament container seal, a transfer needle sealed within the housing via a housing seal, and a connection assembly that is configured to secure the medicament container within the housing such that the medicament container seal opposes the housing seal, the method comprising:

• arranging, via the connection assembly, an outer sealing surface of the medicament container seal in an opposing relationship with an outer sealing surface of the housing seal;
• arranging a heating element between the outer sealing surface of the medicament container seal and the outer sealing surface of the housing seal such that the heating element is in contact with the outer sealing surface of the medicament container seal and the outer sealing surface of the housing seal;
• applying, via the connection assembly and with the heating element between the outer sealing surface of the medicament container seal and the outer sealing surface of the housing seal, force to at least one of the medicament container or the housing such that the outer sealing surface of the medicament container seal and the outer sealing surface of the housing seal are biased towards each other;
• sterilizing, concurrently with applying the force, the outer sealing surface of the medicament container seal and the outer sealing surface of the housing seal by heating, with the heating element, the outer sealing surface of the medicament container seal and the outer sealing surface of the housing seal to a predetermined temperature for a predetermined period of time;
• removing the heating element from between the medicament container seal and the housing seal while continuing to apply the force such that the aseptic connection is simultaneously formed between the outer sealing surfaces outer sealing surface of the medicament container seal and the outer sealing surface of the housing seal without breaking the medicament container seal or the housing seal;
• and
• fixing, with the connection assembly, the medicament container in a final position that maintains the aseptic connection between the outer sealing surface of the medicament container seal and the outer sealing surface of the housing seal.