Pharmaceutical compositions of Gd-based contrast agents

A pharmaceutical composition comprising a gadolinium complex, a C12-C16 saturated tetraazamacrocycle, and a pharmaceutically acceptable carrier, galenic diluent or excipient, wherein an amount of the gadolinium complex is in the form of salt (1:1) with the C12-C16 saturated tetraazamacrocycle, and a remaining amount of the gadolinium complex is in the form of a pharmaceutically acceptable salt with a cation of (i) an inorganic base selected from an alkali and alkaline-earth metal, (ii) an organic base selected from ethanolamine, diethanolamine, morpholine, glucamine, N-methylglucamine, and N,N-dimethylglucamine or (iii) an amino acid selected from lysine, arginine and ornithine.