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US 12,685,786 B2Granted
Treatment of nerve damage using 5'UTR of Gpr151 gene or variant thereof
AssigneeDaegu Gyeongbuk Institute of Science and Technology (Dgist)
InventorsYongcheol Cho, Jung Eun Shin, Jinyoung Lee, Bohm Lee, Yewon Jeon
Life of this patent
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Abstract
Disclosed is a composition for treating a neurological disease caused by nerve injury, including an isolated polynucleotide of a 5′-untranslated region (5′UTR) of a Gpr151 gene or a variant thereof. Also disclosed are a novel variant polynucleotide of 5′UTR of a Gpr151 gene and a vector including the polynucleotide.
Claims11
An isolated polynucleotide consisting of a nucleic acid sequence of SEQ ID NO:
- 7 or SEQ ID NO:
- 10.
A method for treating a neurological disease caused by nerve injury comprising the step of:
- administering to a subject a pharmaceutical composition comprising an isolated 5′-untranslated region (5′UTR) polynucleotide of a Gpr151 gene, a variant thereof, or a DNA encoding the 5′UTR polynucleotide or the variant,
- wherein the 5′UTR polynucleotide and the variant include nAAGmA in a wild-type sequence of the 5′UTR of a Gpr151 gene, wherein n is c, g or u, and m is a, u or g.
Dependencies are inferred from the claim text.