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US 12,685,775 B2Granted
Oligonucleotides with nucleoside analogs
AssigneeSirnaomics, Inc.
InventorsDavid M. Evans, Patrick Y. Lu, Xiaoyong Lu, Eric Roesch
Life of this patent
Estimating the term…
Abstract
siRNA compositions are provided that contain gemcitabine (GEM) in place of cytosine moieties within the siRNA sequence. Pharmaceuticals compositions containing these siRNA molecules, and methods of using the compositions for treating diseases such as cancer are provided.
Claims10
An siRNA comprising a sense strand having the sequence:
- (SEQ ID NO:
- 18)
- 5′-CCU GUG GAA UAG UAC UUA CUG CAA U-3′
- and an antisense strand having the sequence
- (SEQ ID NO:
- 2)
- 5′-A UUG CAG UAA GUA CUA UUC CAC AGG-3′,
- wherein one or more cytosine moieties within the sense strand are replaced by a gemcitabine moiety.
5 more elements
An siRNA sequence against mouse and human genes for RAD17, wherein the sense strand (SS) is
- RAD17_7(6):
- (SEQ ID NO:
- 23)
- SS-5′CCAACAAUUAUGAUGAAAUUUCUUA-3′
- and wherein one or more cytosine moieties within the sense strand are replaced by a gemcitabine moiety.
2 more elements
Dependencies are inferred from the claim text.