Back to results
US 12,685,770 B2Granted
Deimmunized flagellin and vaccine composition comprising same
AssigneeFlagImmune
InventorsJoon Haeng Rhee, Shee Eun Lee, Koemchhoy Khim, Sao Puth
Life of this patent
Estimating the term…
Abstract
The present invention relates to: deimmunized flagellin that does not induce the production of flagellin-specific antibodies; and use thereof. In particular, the present invention relates to a flagellin variant in which a major epitope that forms an antibody against flagellin is deleted, the flagellin variant being characterized by, when used as a vaccine adjuvant, not producing antibodies against flagellin while maintaining an excellent immune enhancer effect.
Claims7
A flagellin variant derived from Vibrio vulnificus comprising:
- N-terminal domain 2, N-terminal domain 3, and C-terminal domain 2,
- wherein the amino acid sequence of SEQ ID NO:
- 1 is deleted from the flagellin variant.
Dependencies are inferred from the claim text.