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AssigneeGlaxosmithkline Biologicals SA
InventorsMaria Paula Carranza Sandmeier, Rainer Follador, Veronica Gambillara Fonck, Stefan Jochen Kemmler, Patricia Martin Killias, Michael Thomas Kowarik, Gerd Martin Lipowsky, Gerald Johann Posch, Fabio Serventi, Dominique Nicolas Sirena
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The present invention relates to the field of immunogenic compositions and vaccines, their manufacture, host cells which can be used in their manufacture and the use of such immunogenic compositions and vaccines in medicine. More particularly, it relates to Klebsiella pneumoniae O-antigens, conjugates comprising a K. pneumoniae O-antigen, host cells suitable for their production and immunogenic compositions or vaccines containing at least one Klebsiella pneumoniae O-antigen.
A host cell comprising:
A conjugate comprising a carrier protein and a Klebsiella pneumoniae O-antigen polysaccharide:
An immunogenic composition comprising one or more carrier proteins, a Klebsiella pneumoniae O1v1 O-antigen polysaccharide, a Klebsiella pneumoniae O2a O-antigen polysaccharide, a Klebsiella pneumoniae O2afg O-antigen polysaccharide, and a Klebsiella pneumoniae O3b O-antigen polysaccharide, wherein each of the Klebsiella pneumoniae O1v1 antigen polysaccharide, the Klebsiella pneumoniae O2a O-antigen polysaccharide, the Klebsiella pneumoniae O2afg O-antigen polysaccharide, and the Klebsiella pneumoniae O3b O-antigen polysaccharide are conjugated to the one or more carrier proteins.
Dependencies are inferred from the claim text.