Modified gene vaccines against avian coronaviruses and methods of using the same
AssigneeWisconsin Alumni Research Foundation
InventorsAdel Talaat, Shaswath Chandrasekar
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Abstract
The present invention provides both QuilA-loaded chitosan (QAC)-encapsulated NA vaccine compositions and viral vaccine compositions that encode an Infectious Bronchitis Virus (IBV) spike (S) protein, an IBV nucleocapsid (N) protein, or both the S protein and the N protein. Additionally, the present invention provides methods in which the disclosed vaccines are administered to a subject to induce an immune response against IBV or to vaccinate the subject against IBV.
Claims20
A vaccine composition comprising a polynucleotide that encodes an infectious bronchitis virus (IBV) spike(S) protein, an IBV nucleocapsid (N) protein, or both the S protein and the N protein, wherein the sequence encoding the S protein comprises one of SEQ ID NOs:
- 22, 24, 26, 28, 30, or 32 or a sequence with at least 90% identity to one of one of SEQ ID NOs:
- 22, 24, 26, 28, 30, or 32 and, wherein the sequence encoding the N protein comprises one of SEQ ID NOs:
- 36 or 38 or a sequence with at least 90% identity to one of SEQ ID NOs:
- 36 or 38.
A vaccine composition comprising a viral vector comprising an infectious bronchitis virus (IBV) (S) protein, an IBV nucleocapsid (N) protein, or both the S protein and the N protein, wherein the viral vector further comprises a polynucleotide encoding the S protein, the N protein or both the S protein and the N protein, and wherein the sequence encoding the S protein comprises one of SEQ ID NOs:
- 22, 24, 26, 28, 30, or 32 or a sequence with at least 90% identity to one of one of SEQ ID NOs:
- 22, 24, 26, 28, 30, or 32 and, wherein the sequence encoding the N protein comprises one of SEQ ID NOs:
- 36 or 38 or a sequence with at least 90% identity to one of SEQ ID NOs:
- 36 or 38.
Dependencies are inferred from the claim text.