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US 12,685,762 B2Granted
Aqueous pharmaceutical composition containing fusion protein of serum albumin and growth hormone
AssigneeJCR Pharmaceuticals Co., Ltd.
InventorsShinji Okabe, Yuka Yamaguchi, Hidehito Yasukawa
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Abstract
An aqueous pharmaceutical composition containing 10-100 mg/mL of a fusion protein of human serum albumin and human growth hormone, 10-150 mg/mL of sucrose, 0.15-10 mg/mL of a nonionic surfactant, 0.5-12 mg/mL of a preservative, and 1-30 mM of a buffer is, and the pH of the composition is 5.0-8.0.
Claims1
An aqueous pharmaceutical composition, comprising:
- a fusion protein of human serum albumin and human growth hormone as an active ingredient at a concentration of 50 mg/mL;
- sucrose at a concentration of 75 mg/mL;
- a nonionic surfactant at a concentration of 3 mg/mL;
- an antiseptic agent at a concentration of 6 mg/mL;
- and
- a buffering agent at a concentration of 10 mM,
- wherein a pH is 7.0 to 7.4,
- wherein
- the nonionic surfactant is polyoxyethylene (160) polyoxypropylene (30) glycol,
- the antiseptic agent is phenol,
- the buffering agent is a phosphate buffering agent, and
- the fusion protein has the amino acid sequence of SEQ ID NO:11.
9 more elements
Dependencies are inferred from the claim text.