Method to increase systemic blood pressure in shock
AssigneeGeorgetown University
InventorsGerard P. Ahern, Thieu X. Phan
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Abstract
Provided herein are methods of stabilizing blood pressure in severe sepsis/septic shock and other types of distributive shock using TRPV1 agonists. Also provided are pharmaceutical formulations for increasing blood pressure in septic shock the formulation including at least one TRPV1 agonist in a dosage form for parenteral administration, wherein the TRPV1 agonist is selected from capsaicin, daphnane TRPV1 agonists, vanillotoxin, N-oleoyl dopamine, N-arachidonyl dopamine, BrP-LPA, and derivatives and analogues thereof. Also provided are TRPV1 agonists co-lyophilized with adrenergic agonists and/or angiotensins in a dosage form for reconstitution and parenteral administration.
Claims20
A method of treatment of hypotension in a human patient in septic shock, the method comprising:
- co-administering at least two TRPV1 agonists to the patient in an amount sufficient to increase and/or maintain a systolic blood pressure of 65 mm Hg or greater in the patient, wherein the at least two TRPV1 agonists comprise BrP-LPA and a vanillotoxin.
A pharmaceutical formulation for increasing blood pressure in a human patient in septic shock, the formulation comprising at least two TRPV1 agonists in a dosage form for parental administration, wherein the at least two TRPV1 agonists comprise BrP-LPA and a vanillotoxin.
Dependencies are inferred from the claim text.