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AssigneesUniversitäT FüR Bodenkultur Wien, Medizinische Universität Wien
InventorsIngo Lämmermann, Johannes Grillari, Vera Pils, Florian Gruber, Marie-Sophie Narzt
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The invention relates to a composition comprising one or more inhibitors capable of inhibiting at least two of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and lipoxygenase or a composition comprising one or more inhibitors capable of inhibiting an enzyme with arachidonate-Co A ligase activity, specifically long-chain-fatty-acid-Co A ligase (ACSL) 1, ACSL3, ACSL4, ACSL5, ACSL6, SLC27A2 or ACSBG2, or a combination thereof for use in selectively eliminating senescent cells. The invention further relates to an in vitro method of identifying senescent cells in a subject and to a method of identifying candidate compounds for the selective elimination of senescent cells.
A method of selectively eliminating senescent skin fibroblasts, senescent lung fibroblasts, senescent umbilical vein endothelial cells, and senescent renal proximal tubule endothelial cells comprising administering a composition comprising an inhibitor of long-chain-fatty-acid-CoA ligase (ACSL) 4 to treat idiopathic pulmonary fibrosis, osteoarthritis, skin wounds, and skin aging in a patient, wherein the ACSL4 inhibitor is triacsin C, and wherein senescent cells are characterized by an increased intracellular level of lysophosphatidylcholine, arachidonic acid and/or phospholipase A2 activity compared to a non-senescent cell of the same type or age.
Dependencies are inferred from the claim text.