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US 12,685,735 B2Granted
BAF complex modulating compounds
AssigneeFoghorn Therapeutics Inc.
InventorsNeville John Anthony, Rishi G. Vaswani, David Simon Millan, Shawn E.R. Schiller, Kevin J. Wilson
Life of this patent
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Abstract
The present disclosure features compounds useful for the treatment of BAF complex-related disorders.
Claims40
A compound having the structure:
- wherein m is 1, 2, 3, or 4;
- n is 0, 1, 2, 3, or 4;
- R1 combines with R2 and the atoms to which they are attached to form a 5- to 7-membered ring;
- each R2 is, independently, halo, hydroxy, thiol, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, or optionally substituted amino, or one R2 combines with another R2 and the atoms to which they are attached to form a 5- to 7-membered ring;
- R3 and R5 are, independently, hydrogen or optionally substituted C1-C6 alkyl;
- R4 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C1-C6 alkyl C6-C10 aryl, or optionally substituted C1-C6 alkyl C2-C9 heteroaryl;
- Het is 5- or 6-membered heterocycle;
- R6 is hydrogen, halo, cyano, optionally substituted C1-C6 alkoxy, optionally substituted C1-C6 heteroalkyl, carboxyl, optionally substituted amide, optionally substituted C2-C9 heteroaryl, optionally substituted C2-C9 heterocyclyl, or optionally substituted C6-C10 aryl;
- and
- R7 is cyano, halo, optionally substituted C1-C6 alkyl or optionally substituted C1-C6 heteroalkyl,
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.