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US 12,685,711 B2Granted
Formulations for pancreatic islet encapsulation
AssigneeWake Forest University Health Sciences
InventorEmmanuel C. Opara
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Abstract
Provided herein according to embodiments of the present invention is a microcapsule comprising: (a) one or more live mammalian pancreatic islet cells; and (b) an alginate composition encapsulating said islet cells, wherein said alginate composition comprises extracellular matrix proteins solubilized or suspended therein. Compositions comprising a plurality of the microcapsules and the use thereof in treating type I diabetes are also provided.
Claims15
A microcapsule comprising:
- (a) one or more live mammalian pancreatic islet cells;
- and
- (b) an alginate composition encapsulating said islet cells,
- wherein said alginate composition comprises extracellular matrix proteins solubilized therein,
- wherein said extracellular matrix proteins are pancreatic extracellular matrix proteins obtained from a decellularized extracellular pancreatic matrix,
- wherein said extracellular matrix proteins are present in an amount of from 0.5 mg per mL to 10 mg per mL of the alginate composition,
- wherein said alginate composition is a high-mannuronic acid (high-M) alginate composition,
- wherein said alginate composition is crosslinked with Sr++, and
- wherein said alginate composition has a storage modulus of from about 0.1 to about 6 kiloPascals.
6 more elements
Dependencies are inferred from the claim text.