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US 12,685,709 B2Granted
Solid solution compositions and use in chronic inflammation
AssigneeInfirst Healthcare Limited
InventorsRobin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
Life of this patent
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Abstract
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
Claims20
A pharmaceutical capsule comprising a fill and a shell,
- the fill comprising
- a) 25% to 31% by weight of non-steroidal anti-inflammatory drug (NSAID), or a pharmaceutically acceptable salt, solvate, or solvate of a salt thereof;
- b) 34% to 40% by weight of a fat comprising a mixture of saturated C10-C18 triglycerides;
- c) 22% to 28% by weight of one or more partially hydrolyzed liquid lipids comprising a mixture of monoglycerides, diglycerides and triglycerides;
- and
- d) 7% to 13% by weight of a liquid polyethylene glycol polymer,
- the shell comprising gelatin, sorbitol, mannitol, and a sorbitan, and
- wherein the pharmaceutical capsule is in an oral dosage form.
5 more elements
A pharmaceutical capsule comprising a fill and a shell,
- the fill comprising
- a) 25% to 31% by weight of an ibuprofen, or a pharmaceutically acceptable salt, solvate, or solvate of a salt thereof;
- b) 35% to 39% by weight of a fat comprising a mixture of saturated C10-C18 triglycerides;
- c) 22% to 28% by weight of a partially hydrolyzed liquid lipids comprising a mixture of monoglycerides, diglycerides and triglycerides, the mixture of monoglycerides, diglycerides and triglycerides including a glycerol monolinoleate;
- and
- d) 7% to 13% by weight of a liquid polyethylene glycol polymer, the liquid polyethylene glycol having a molecular weight of no more than 800 g/mol,
- the shell comprising gelatin, sorbitol, mannitol, and a sorbitan, and
- wherein the pharmaceutical capsule is in an oral dosage form.
5 more elements
Dependencies are inferred from the claim text.