Genetically modified mouse, methods for producing the same, and uses thereof
AssigneeMackay Memorial Hospital
InventorsKate Hsu, Li-Yang Chen, Pin-Lung Chen
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Abstract
Disclosed herein is a genetically modified mouse whose genome comprises a transgene encoding a Miltenberger blood group antigen subtype III (Mi.II antigen). According to embodiments of the present disclosure, the Mi.III antigen comprises the amino acid sequence of SEQ ID NO: 1. Also disclosed herein are a method of producing the genetically modified mouse, and uses of the genetically modified mouse in selecting a drug candidate for treating hypertension.
Claims17
A genetically modified mouse whose genome comprises a transgene encoding a Miltenberger blood group antigen subtype III (Mi.III antigen) comprising the amino acid sequence of SEQ ID NO:
- 1, wherein the transgene comprises a nucleotide sequence at least 85% identical to SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.