Photoactive fluorescent compounds and use thereof for labeling of proteins
AssigneeEikon Therapeutics, Inc.
InventorsHilary Plake Beck, David Trombley Mcswiggen, Leah Brigit Cleary, Daniel James Anderson, Yihong Li, Anne Ruth Sizemore
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Abstract
Provided herein are novel photoactive fluorescent compounds of Formula (A) or a salt, a single stereoisomer, a mixture of stereoisomers or an isotopic form thereof, wherein G, R, X, Z, and LA are as defined herein, and their use in labeling proteins, for example, tagged proteins, comprising their use for visualizing the location and dynamics of proteins in living cells:
Claims10
A compound, having a structure of Formula (IV):
- wherein R1 is —OH, —C(═O)OH, —C(═O)O(C1-3 alkyl), —C(═O)N(C1-3 alkyl)2, —N(C1-3 alkyl)2, —(CH2)nO(C1-3 alkyl),
A compound having the following structure:
A compound having the following structure:
A compound having the following structure:
A compound having the following structure:
Dependencies are inferred from the claim text.