Pro-adrenomedullin for prognosing disease progression in severe acute respiratory syndrome (SARS)
OwnerStefan Ebmeyer, Manne Krop +1inventors
InventorsStefan Ebmeyer, Manne Krop, Jutta Odarjuk
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Abstract
The invention relates to a method for prognosing disease progression in a patient that has or is at risk of developing a severe acute respiratory syndrome (SARS), wherein the method comprises determining a level of pro-adrenomedullin (proADM) or fragment(s) thereof in a sample from the patient, wherein said level indicates the severity of SARS progression. The method is in some embodiments configured for use when a patient exhibits symptoms of a severe acute respiratory syndrome (SARS), a patient exhibits symptoms of infection with a SARS-virus, the patient is infected with a SARS-virus, such as a SARS-coronavirus, such as SARS-CoV2.
Claims16
A method for reducing the risk of severe acute respiratory syndrome (SARS) progression in a patient that has SARS, wherein the patient is infected with a SARS-coronavirus, wherein the method comprises determining a level of mid-regional pro-adrenomedullin (MR-proADM) in a sample from the patient, wherein said level indicates the severity of SARS progression, comprising prognosing a subsequent adverse event in the health of the patient, wherein the patient has been diagnosed with SARS, wherein the level of MR-proADM indicates the likelihood of a subsequent adverse event in the health of said patient and treating said patient to reduce the risk of SARS progression, wherein the treatment comprises one or more of a transfer to a clinical setting for intensified treatment, hospitalization, an escalation of therapeutic interventions, symptomatic treatment, treatment to reduce fever and/or pain, anti-inflammatory treatment, antiviral treatment, antibiotic treatment, oxygen support, invasive mechanical ventilation, non-invasive mechanical ventilation, renal replacement therapy, vasopressor use, fluid therapy, extracorporeal blood purification and/or organ protection.
Dependencies are inferred from the claim text.