Continuous sensing with adapters and aptamers
AssigneeUniversity of Cincinnati
InventorJason Heikenfeld
Life of this patent
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Abstract
A device and method for detecting the presence of, or measuring the concentration of amount of, at least one analyte in a sample fluid. The device includes a sensor fluid (18), a plurality of adapter molecules (980) in the sensor fluid that are capable of binding to an analyte, a plurality of aptamers (970) in the sensor fluid that are capable of binding to the analyte when analyte is bound to one or more adapter molecules of the plurality of adapter molecules, at least one membrane (936) in communication with the sensor fluid, and at least one detection component that is capable of detecting the binding of analyte by one or more of the plurality of aptamers. The membrane is permeable to the analyte but impermeable to the adapter molecule.
Claims47
A device for detecting the presence of, or measuring the concentration of amount of, at least one analyte in a sample fluid, the device comprising:
- a sensor fluid;
- a plurality of adapter molecules in the sensor fluid that are capable of binding to an analyte;
- a plurality of aptamers in or exposed to the sensor fluid that are capable of binding to the analyte when analyte is bound to one or more adapter molecules of the plurality of adapter molecules;
- at least one membrane in communication with the sensor fluid, wherein the membrane is permeable to the analyte but impermeable to the adapter molecule;
- and
- at least one detection component that is capable of detecting the binding of analyte by one or more of the plurality of aptamers.
Dependencies are inferred from the claim text.