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US 12,680,120 B2Granted
Corynebacterium glutamicum mutant strain having enhanced l-lysine productivity and method of producing L-lysine using the same
AssigneeDaesang Corporation
InventorsMi Ryu, In Pyo Hong, Min Jin Choi, Seok Hyun Park, Jae Chun Han
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Abstract
The present disclosure relates to a Corynebacterium glutamicum mutant strain having enhanced L-lysine productivity and a method of producing L-lysine using the same. The Corynebacterium glutamicum mutant strain may produce L-lysine in an improved yield by inhibiting the conversion of oxaloacetate to citrate due to decreased or inhibited expression of the gene encoding the citrate synthase.
Claims1
A Corynebacterium glutamicum mutant strain having enhanced L-lysine productivity due to weakened activity of citrate synthase compared to an unmodified Corynebacterium glutamicum,
- wherein the weakened activity of the citrate synthase is achieved by replacement of a start codon of a gene encoding the citrate synthase comprising the nucleotide sequence of SEQ ID NO:
- 1 with TTG.
Dependencies are inferred from the claim text.