Cancer antigens and methods
AssigneesEnara Bio Limited, The Francis Crick Institute Limited
InventorsGeorge Kassiotis, George Young, Jan Attig, Fabio Marino
Life of this patent
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Abstract
There are disclosed inter alia polypeptides and nucleic acids encoding said polypeptides which are useful in the treatment, prevention and diagnosis of cancer, particularly non small cell lung cancer, especially lung squamous cell carcinoma and melanoma, especially cutaneous melanoma.
Claims20
A composition comprising an isolated polypeptide and an immunostimulant, wherein:
- (a) the isolated polypeptide consists of an amino acid sequence comprising at least 9 contiguous residues of SEQ ID NO:
- 1 or 2;
- (b) the isolated polypeptide comprises an amino acid sequence having at least 90% identity over the entire length of SEQ ID NO:
- 1 or 2;
- (c) the isolated polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-4;
- or
- (d) the amino acid sequence of the isolated polypeptide consists of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-4.
A fusion protein comprising a first polypeptide and one or more additional polypeptides, wherein the first polypeptide:
- (a) consists of an amino acid sequence comprising at least 9 contiguous residues of SEQ ID NO:
- 1 or 2;
- (b) comprises an amino acid sequence having at least 90% identity over the entire length of SEQ ID NO:
- 1 or 2;
- (c) comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-4;
- or
- (d) consists of an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 1-4.
A vector or artificial nucleic acid sequence encoding a polypeptide, wherein the polypeptide:
- (a) consists of an amino acid sequence comprising at least 9 contiguous residues of SEQ ID NO:
- 1 or 2;
- (b) comprises an amino acid sequence having at least 90% identity over the entire length of SEQ ID NO:
- 1 or 2;
- (c) comprises the amino acid sequence of SEQ ID NO:
- 1 or 2;
- or
- (d) consists of an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 1-4.
An exosome comprising a polypeptide or a nucleic acid sequence encoding the polypeptide, wherein the polypeptide:
- (a) comprises an amino acid sequence comprising at least 9 contiguous residues of SEQ ID NO:
- 1 or 2;
- (b) comprises an amino acid sequence having at least 90% identity over the entire length of SEQ ID NO:
- 1 or 2;
- (c) comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-4;
- or
- (d) consists of an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 1-4.
A method of diagnosing a subject as suffering from a cancer, the method comprising determining if cells of the subject comprise a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 or 2, or an immunogenic fragment or variant thereof, or a nucleic acid sequence expressing the polypeptide, wherein the presence of the polypeptide or nucleic acid sequence in the cells indicates that the subject has cancer.
An isolated peptide:
- (i) comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1 and 2;
- (ii) consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-4;
- or
- a salt thereof, and/or a composition thereof.
Dependencies are inferred from the claim text.