Poly[alpha-cyanoacrylate] hydrolyzate and preparation method and application thereof

A method comprising the steps of:

• preparing an alkyl α-cyanoacrylate polymer;
• forming a dispersion of the alkyl α-cyanoacrylate polymer in anhydrous ethanol;
• adding an aqueous base to the dispersion to hydrolyze the alkyl α-cyanoacrylate polymer under alkaline conditions to obtain a hydrolysate solution, wherein:
• all ester bonds of the alkyl α-cyanoacrylate polymer are hydrolyzed selectively under alkaline conditions and cyano groups are retained, and the hydrolysate solution includes poly[2-cyanoacrylic acid] dissolved in water, or
• all ester bonds and cyano groups of the alkyl α-cyanoacrylate polymer are hydrolyzed, and the hydrolysate solution includes poly[2-carboxyacrylic acid] dissolved in water;
• and
• for the hydrolysate solution that includes poly[2-cyanoacrylic acid]:
• separating the poly[2-cyanoacrylic acid] from the hydrolysate solution and preparing a blank embolic microsphere using the poly[2-cyanoacrylic acid];
• for the hydrolysate solution that includes poly[2-carboxyacrylic acid]:
• separating the poly[2-carboxyacrylic acid] from the hydrolysate solution and preparing a nano-drug carrier using the poly[2-carboxyacrylic acid].