Cancer vaccines targeting Survivin and uses thereof
AssigneeInovio Pharmaceuticals, Inc.
InventorsJian Yan, Anna Slager, Bradley Garman, Neil Cooch
Life of this patent
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Abstract
Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens. Vectors, compositions, and vaccines comprising one or more nucleic acid sequences that encode synthetic consensus Survivin antigens are disclosed. Methods of treating a subject with a Survivin-expressing tumor and methods of preventing a Survivin-expressing tumor are disclosed. Synthetic consensus Survivin antigens are disclosed.
Claims9
A nucleic acid molecule comprising one or more nucleic acid sequences selected from the group consisting of:
- (a) SEQ ID NO:
- 9;
- (b) SEQ ID NO:
- 10;
- (c) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:
- 9 encoding SEQ ID NO:
- 11, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 33, 47, and 83 of SEQ ID NO:
- 11;
- and
- (d) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:
- 10 encoding SEQ ID NO:
- 13, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 33, 47, and 83 of SEQ ID NO:
- 13.
A nucleic acid molecule comprising one or more nucleic acid sequences selected from the group consisting of:
- (a) SEQ ID NO:
- 1;
- (b) SEQ ID NO:
- 3;
- (c) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:
- 1 encoding SEQ ID NO:
- 2, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 51, 65, and 101 of SEQ ID NO:
- 2;
- and;
- (d) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:3 encoding SEQ ID NO:
- 8, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 51, 65, and 101 of SEQ ID NO:
- 8.
A nucleic acid molecule comprising the nucleic acid sequence set forth in SEQ ID NO:
- 1.
A nucleic acid molecule comprising the nucleic acid sequence set forth in SEQ ID NO:3.
A vector comprising a nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of:
- (a) SEQ ID NO:
- 9;
- (b) SEQ ID NO:
- 10;
- (c) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:
- 9 encoding SEQ ID NO:
- 11;
- wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 33, 47, and 83 of SEQ ID NO:
- 11;
- (d) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:
- 10 encoding SEQ ID NO:
- 13, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 33, 47, and 83 of SEQ ID NO:
- 13;
- (e) SEQ ID NO:1;
- (f) SEQ ID NO:3;
- (g) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:1 encoding SEQ ID NO:
- 2, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 51, 65, and 101 of SEQ ID NO:
- 2;
- and;
- (h) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:3 encoding SEQ ID NO:
- 8, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 51, 65, and 101 of SEQ ID NO:
- 8.
A composition comprising one or more nucleic acid molecules comprising a nucleic acid sequence selected from the group consisting of:
- (a) SEQ ID NO:9;
- (b) SEQ ID NO:10;
- (c) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:
- 9 encoding SEQ ID NO:
- 11, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 33, 47, and 83 of SEQ ID NO:
- 11;
- (d) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:
- 10 encoding SEQ ID NO:
- 13, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 33, 47, and 83 of SEQ ID NO:
- 13;
- (e) SEQ ID NO:1;
- (f) SEQ ID NO:3;
- (g) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:
- 1 encoding SEQ ID NO:
- 2, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 51, 65, and 101 of SEQ ID NO:
- 2;
- and
- (h) a nucleic acid sequence that is at least 95% identical to SEQ ID NO:3 encoding SEQ ID NO:
- 8, wherein the nucleic acid sequence encodes a protein comprising SEQ ID NO:
- 5 and an alanine at positions 51, 65, and 101 of SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.