Antibody for specifically binding to lysyl-tRNA synthetase N-terminal domain exposed to extracellular membrane

An antibody or fragment thereof that specifically binds to an extracellularly exposed lysyl-tRNA synthetase (KRS)N-terminal region, the antibody or fragment thereof comprises:

• (a) a heavy chain variable region (VH) comprising
• (i) heavy chain complementarity determining region 1 (CDR1) containing the amino acid sequence SYDMS (SEQ ID NO:
• 1);
• (ii) heavy chain complementarity determining region 2 (CDR2) containing the amino acid sequence X1|X2X3X4X5GX6X7YYADSVKG (SEQ ID NO:
• 252), wherein X1 is A or V, X2 is S, D or G, X3 is Y, P, S or A, X4 is D, Q, L or Y, X5 is N, M, S, or G, X6 is N, R or P, X7 is T, V, I or S;
• and
• (iii) heavy chain complementarity determining region 3 (CDR3) containing the amino acid sequence X8ALDFDY (SEQ ID NO:
• 253), wherein X8 is M or L, and
• (b) a light chain variable region (VL) comprising
• (i) light chain complementarity determining region 1 (CDR1) containing the amino acid sequence TGSSSNIGSNYVT (SEQ ID NO:
• 7);
• (ii) light chain complementarity determining region 2 (CDR2) containing the amino acid sequence X9NX10X11RPS (SEQ ID NO:
• 254), wherein X9 is D, S or R, X10 is S or N, and X11 is N or Q;
• and
• (iii) light chain complementarity determining region 3 (CDR3) containing the amino acid sequence X12SFSDELGAYV (SEQ ID NO:
• 255), wherein X12 is A or S.