Anti-TLR7 agents and compositions and methods for making and using the same
AssigneeBiolegend, Inc.
InventorsTakatoku Oida, Anagha Ashok Divekar, Shawna Ann Shirley, Nicole Vivienne Acuff
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Abstract
Compositions and methods for making and using anti-TLR7 agents, for example, monoclonal antibodies, TLR7-binding antibody fragments, and derivatives are described, as are kits, nucleic acids encoding such molecules, diagnostic reagents and kits that include anti-TLR7 agents, and methods of making and using the same.
Claims19
An anti-TLR7 agent that binds Toll-like Receptor 7 (TLR7), comprising an immunoglobulin heavy chain variable domain and an immunoglobulin light chain variable domain, wherein the immunoglobulin heavy chain variable domain comprises a set of CDRH1, CDRH2, and CDRH3 amino acid sequences and the immunoglobulin light chain variable domain comprises a set of CDRL1, CDRL2, and CDRL3 amino acid sequences, wherein the amino acid sequences for the immunoglobulin heavy chain variable domain and the immunoglobulin light chain variable domain comprise sequences selected from one of sets 1-6:
- CDRH1
- CDRH2
- CDRH3
- CDRL1
- CDRL2
- CDRL3
- set
- (SEQ ID NO:)
- (SEQ ID NO:)
- (SEQ ID NO:)
- (SEQ ID NO:)
- (SEQ ID NO:)
- (SEQ ID NO:)
- 1
- DYWMS (1)
- DIKYDGSFID
- DLTTVVDGFAY
- RASQSLSTSI
- YASQPIS (24)
- QQSYSSPYT
- YAPSLKN (6)
- (12)
- H (19)
- (29)
- 2
- DYWMS (1)
- DIKYDGTFI
- DLTTVVDGFAY
- RASQSLSTSI
- YASQPIS (24)
- QQSYSSPYT
- DYAPSLKN
- (12)
- H (19)
- (29)
- (7)
- 3
- NYYMA (2)
- SITNSGRTTY
- EGGDLYYSN
- LPSEDIYNN
- YASNLQD
- LQDSDYPFT
- YRDSVKG
- YNYVRFAY
- LA (18)
- (23)
- (28)
- (8)
- (13)
- 4
- DYYMA (3)
- SISYEGSSTH
- HGGYPNWYFDF
- RASEDIYNE
- NANSLHT
- QQYYDYPW
- YGDSVKA
- (14)
- LA (17)
- (22)
- T (27)
- (9)
- 5
- DYCVH (4)
- YINPYSGYT
- GPYGGYSGDGFDY
- RASEDIYNV
- NANRLHN
- QQYYDYPN
- NYNEKFKS
- (15)
- LA (16)
- (20)
- T (25)
- (10)
- 6
- DYYIH (5)
- FINPDSGYT
- GPYGGYSGDGFDY
- RASEDIYNV
- NANNLHT
- QQYYDYPH
- NYNEKFKT
- (15)
- LA (16)
- (21)
- T (26)
- and wherein all CDR amino acid sequences are from the same set.
Dependencies are inferred from the claim text.