US 12,679,887 B2 · Anti-interleukin-17A antibody, pharmaceutical composition thereof and use thereof

Abstract

The present invention relates to the fields of treating autoimmune diseases and molecular immunology, and specifically, to an anti-IL-17A antibody, a pharmaceutical composition thereof, and use thereof. The present invention relates to a monoclonal antibody or an antigen binding fragment thereof, wherein a heavy chain variable region of the monoclonal antibody comprises: HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 31-33 respectively, or HCDR1-HCDR3 with amino acid sequences set forth in SEQ ID NOs: 37-39 respectively, and a light chain variable region of the monoclonal antibody comprises: LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NOs: 34-36 respectively, or LCDR1-LCDR3 with amino acid sequences set forth in SEQ ID NOs: 40-42 respectively. Monoclonal antibodies of the present invention can specifically antagonize the binding of IL-17A to a ligand and inhibit activation of fibroblasts by IL-17A.

Claims10

Dependent claims

An anti-interleukin-17A (anti-IL-17A) monoclonal antibody or an antigen-binding fragment thereof comprising:

a) a heavy chain variable region (VH) comprising three complementarity determining regions (HCDRs):
HCDR1 having the amino acid sequence set forth in SEQ ID NO:
31,
HCDR2 having the amino acid sequence set forth in SEQ ID NO:
32, and
HCDR3 having the amino acid sequence set forth in SEQ ID NO:
33;
and
b) a light chain variable region (VL) comprising three CDRs (LCDRs):
LCDR1 having the amino acid sequence set forth in SEQ ID NO:
34,
LCDR2 having the amino acid sequence set forth in SEQ ID NO:
35, and
LCDR3 having the amino acid sequence set forth in SEQ ID NO:
36.

12 more elements

Dependencies are inferred from the claim text.

Anti-interleukin-17A antibody, pharmaceutical composition thereof and use thereof

Life of this patent

Anti-interleukin-17A antibody, pharmaceutical composition thereof and use thereof

Life of this patent

Abstract

Claims10