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US 12,679,876 B2Granted
Activin/BMP7 chimeras: super-active SAB704 and SAB715, and their respective nogginsensitized variants, NAB704 and NAB715; and NAB204
AssigneeOSR Holdings Co., Ltd.
InventorsSeunghyon Choe, So-Mi Yoon
Life of this patent
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Abstract
The present disclosure relates to chimeric polypeptide having TGF-beta activity, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides with improved or novel biological and therapeutic properties.
Claims5
A recombinant polypeptide comprising an amino acid selected from the group consisting of SEQ ID NO:
- 8, SEQ ID NO:
- 10 and SEQ ID NO:
- 12, wherein the recombinant polypeptide modulates the SMAD pathway.
Dependencies are inferred from the claim text.