Aryl-substituted n-alkyl indoles and their use as pharmacologically active agents

An aryl-substituted N-alkyl indole having the structure of formula

• wherein:
• m, p, and q are independently selected from zero and 1;
• L1 is selected from C1-C3 alkylene and C2-C3 alkenylene, and is optionally substituted with hydroxyl, C1-C3 alkoxy, or halo;
• L2 is selected from —(CO)— and —(SO2)—;
• L3 is selected from C2-C3 alkylene and C2-C3 alkenylene, and is optionally substituted with hydroxyl, C1-C3 alkoxy, or halo;
• R1 is H or C1-C3 alkyl;
• R2 is selected from C1-C3 alkyl, C2-C3 alkenyl, halogenated C1-C3 alkyl, halogenated C2-C3 alkenyl, hydroxyl, hydroxyl-substituted C1-C3 alkyl, C1-C3 alkoxy, cyano, amino, mono-C1-C3 alkyl-substituted amino, di-C1-C3 alkyl-substituted amino, and morpholinyl;
• R3 is selected from hydroxyl, C1-C3 alkoxy, and amino;
• R4 and R5 are independently selected from H and C1-C3 alkyl or are linked to form an aliphatic N-heterocycle optionally substituted with one or two non-hydrogen substituents selected from C1-C3 alkyl, hydroxyl, and C1-C3 alkoxy, or wherein two non-hydrogen substituents on the aliphatic N-heterocycle are linked to form a bridged bicyclic moiety comprising a 1-, 2-, or 3-carbon atom bridge;
• and
• Ar is bicyclic N-heteroaryl bound to L3 through a ring carbon atom and is optionally substituted with at least one substituent selected from hydroxyl, amido, mono-(C1-C3 alkyl)amido, di-(C1-C3 alkyl)amido, and C2-C3 acylamino.