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US 12,679,837 B2Granted
Aminopyrimidine compound as CDK2/4/6 triple inhibitor
AssigneeCisen Pharmaceutical Co., Ltd.
InventorsMing Zhou, Zhaobing Xu, Gang Li, Lihong Hu, Charles Z. Ding, Wen Jiang, Guoping Hu, Jian Li, Shuhui Chen
Life of this patent
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Abstract
Disclosed is an aminopyrimidine compound as a CDK2/4/6 inhibitor, and specifically disclosed are the compound represented by formula (I) and a pharmaceutically acceptable salt thereof, and an application of the compound represented by formula (I) and the pharmaceutically acceptable salt thereof in the preparation of a medicament for treating solid tumor.
Claims16
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof,
- wherein,
- T is N or CH;
- R1 is
- R2 and R3 are each independently H, F, Cl, Br, I, —CN, —OH, C1-3 alkoxy or C1-3 alkyl, wherein the C1-3 alkoxy and the C1-3 alkyl are optionally substituted with 1, 2 or 3 substituents independently selected from F, Cl, Br, —CN, —OH and —NH2;
- or R2 and R3 are joined together with the carbon atom to which they are attached form C3-5 cycloalkyl, wherein the C3-5 cycloalkyl is optionally substituted with 1, 2 or 3 Rb;
- each Rb is independently H, F, Cl, Br, I, —CN, —OH, C1-3 alkoxy, C1-3 alkyl or C1-3 haloalkyl;
- R4 and R5 are each independently H, F, Cl, Br, I, —CN, —OH, C1-3 alkoxy or C1-3 alkyl, wherein the C1-3 alkoxy and the C1-3 alkyl are optionally substituted with 1, 2 or 3 substituents independently selected from F, Cl, Br, —CN, —OH and —NH2;
- or R3 and R4 are joined together with the carbon atom to which they are attached form C3-5 cycloalkyl, wherein the C3-5 cycloalkyl is optionally substituted with 1, 2 or 3 Rc;
- each Rc is independently H, F, Cl, Br, I, —CN, —OH, C1-3 alkoxy, C1-3 alkyl or C1-3 haloalkyl;
- R6 is H, F, Cl, Br, I, —CN, —OH, C1-3 alkoxy, C1-3 alkyl or C1-3 haloalkyl;
- R7 is —NH2, C1-3 alkylamino, C1-6 alkyl, C3-5 cycloalkyl, 4- to 6-membered heterocycloalkyl, 5- to 6-membered heteroaryl or phenyl, wherein the C1-6 alkyl, the C3-5 cycloalkyl, the 4- to 6-membered heterocycloalkyl, the 5- to 6-membered heteroaryl and the phenyl are optionally substituted with 1, 2 or 3 Rd;
- each Rd is independently H, F, Cl, Br, I, —CN, —OH, C1-3 alkoxy or C1-3 alkyl, wherein the C1-3 alkoxy and the C1-3 alkyl are optionally substituted with 1, 2 or 3 substituents independently selected from F, Cl, Br, —CN, —OH and —NH2;
- n is 0, 1 or 2;
- the 4- to 6-membered heterocycloalkyl and the 5- to 6-membered heteroaryl respectively comprise 1, 2, 3 or 4 heteroatoms independently selected from N, —O— and —S—.
11 more elements
Dependencies are inferred from the claim text.