Thiophenoxime and furanoxime scaffolds
AssigneesCentre National De La Recherche Scientifique, Etat FrançAis, Service De Santé Des ArméEs RepréSéNté Par Le DéLéGué GéNéRal De L'armement, Universite De Strasbourg
InventorsRachid Baati, Mallikarjuna Reddy Nimmakayala, José Dias, Florian Nachon, Camille Voros, Raymond Franck Razafindrainibe
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Abstract
The present invention relates to a compound of formula (I). It also relates to a pharmaceutical composition comprising at least one compound of formula (I) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and/or respiratory failure due to intoxication with at least one organophosphorous nerve agent; in the treatment of neurological diseases such as Alzheimer's disease; and/or in the treatment of cancer.
Claims5
A compound, or a salt thereof, selected from the group consisting of:
- (E/Z)-5-(pyridin-3-ylethynyl)thiophene-2-carbaldehyde oxime 4:
- (E/Z)-5-(pyridin-3-ylethynyl)thiophene-2-carbaldehyde oxime hydrochloride NM-27:
- (E/Z)-5-(2-(pyridin-3-yl)ethyl)thiophene-2-carbaldehyde oxime 5:
- (E/Z)-5-(2-(pyridin-3-yl)ethyl)thiophene-2-carbaldehyde oxime hydrochloride NM-29:
- (E/Z)-5-(pyridin-3-ylethynyl)furan-2-carbaldehyde oxime 8:
- (E/Z)-5-(2-(pyridin-3-yl)ethyl)furan-2-carbaldehyde oxime 9:
- (E/Z)-5-(2-(pyridin-3-yl)ethyl)furan-2-carbaldehyde oxime hydrochloride NM-34:
- (E/Z)-5-(4-(quinolin-4-ylamino)but-1-yn-1-yl)furan-2-carbaldehyde oxime 11:
- (E/Z)-5-(4-(quinolin-4-ylamino)but-1-yn-1-yl)furan-2-carbaldehyde oxime hydrochloride NM-53:
- (E/Z)-5-(4-(quinolin-4-ylamino)butyl)furan-2-carbaldehyde oxime 14:
- (E/Z)-5-(4-(quinolin-4-ylamino)butyl)furan-2-carbaldehyde oxime hydrochloride NM-80:
- (Z/E)-5-(4-(1,3-dioxoisoindolin-2-yl)but-1-yn-1-yl)thiophene-2-carbaldehyde oxime CV-65:
- (Z/E)-5-((1-methyl-1H-imidazol-5-yl)ethynyl)furan-2-carbaldehyde oxime 5:
- (E/Z)-5-(2-(1-methyl-1H-imidazol-5-yl)ethyl)furan-2-carbaldehyde oxime 6:
- (Z)-5-(2-(1-methyl-1H-imidazol-5-yl)ethyl)furan-2-carbaldehyde oxime hydrochloride FR-152:
- (3aS,4S,6R,6aR)-6-(6-amino-9H-purin-9-yl)-N-(4-(5-((Z)-(hydroxyimino)methyl)furan-2-yl)but-3-yn-1-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carboxamide FR-151:
- (Z/E)-5-((3-hydroxyoxetan-3-yl)ethynyl)furan-2-carbaldehyde oxime FR-99:
- (Z/E)-5-(4-(1,3-dioxoisoindolin-2-yl)but-1-yn-1-yl)furan-2-carbaldehyde oxime CV-59:
- (Z/E)-5-(4-(1,3-dioxoisoindolin-2-yl)butyl)furan-2-carbaldehyde oxime CV-60
- (E/Z)-4-(pyridin-3-ylethynyl)furan-2-carbaldehyde oxime 3:
- (E/Z)-4-(2-(pyridin-3-yl)ethyl)furan-2-carbaldehyde oxime FR-82:
- (Z/E)-4-(5-phenylpent-1-yn-1-yl)furan-2-carbaldehyde oxime FR-66:
Dependencies are inferred from the claim text.