Amino lipid and preparation method and application thereof

Abstract

An amino lipid and its preparation method as well as an application thereof is provided, and also provided are ionizable amino lipids with a general formula as shown in Formula (I), or pharmaceutically acceptable salts thereof. The amino lipids are used for delivering nucleic acids and small-molecule drugs. The amino lipid compounds have two ester bonds, which enhance the lysosome escape capability of the ionizable amino lipids, and are favorable for the release of delivery targets of a targeted drug or gene, etc., thus improving the delivery efficiency, and showing the capability of delivering nucleic acids into cells in the in-vitro and in-vivo delivery studies.

Dependencies are inferred from the claim text.