Systems and methods for closed-loop or partially closed-loop baroreflex activation therapy

A method of delivering baroreflex activation therapy to a patient in a closed-loop or partially closed-loop configuration, the method comprising:

• delivering electrical stimulation to a baroreceptor region with a pulse generator;
• collecting physiological data from at least one sensor configured to monitor one or more of electrocardiography (ECG), rate variability (HRV), blood pressure, bioimpedance, acoustics, electromyography (EMG), and physical activity;
• analyzing the collected data to assess autonomic nervous system activity;
• and
• adjusting at least one stimulation parameter in response to the analysis to modulate baroreflex activity,
• wherein the adjusting occurs on a beat-to-beat basis using ECG input, and wherein the adjusted stimulation parameter comprises a duty cycle that is dynamically modulated based on time of day or detected patient activity.

A baroreflex activation therapy system configured for closed-loop or partially closed-loop operation, comprising:

• a pulse generator configured to deliver electrical stimulation to one or more baroreceptors;
• a sensor suite configured to collect physiological data including at least electrocardiography heart rate variability (HRV);
• and
• a controller programmed to analyze the collected physiological data and adjust two or more stimulation parameters in response,
• wherein the controller autonomously adjusts stimulation on a beat-to-beat basis using ECG input such that stimulation is synchronized to the cardiac cycle based on timing information derived from ECG, and wherein the beat-to-beat adjusting is performed independently of longer-term duty-cycle scheduling or circadian therapy programming.