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US 12,678,593 B2Granted
Therapeutic agent delivery system with delayed activation
AssigneeTriSalus Life Sciences, Inc.
InventorsDavid Benjamin Jaroch, James E. Chomas, Bryan Pinchuk, Aravind Arepally
Life of this patent
Estimating the term…
Abstract
Systems with pressure-responsive elements for monitoring intravascular pressure are also provided to time delivery of the therapeutic agent for maximum uptake by the target organ. Methods for treating tissues and organs via vascular pathways are provided.
Claims22
A system for infusing a therapeutic agent through a primary vessel and into a feeder vessel in a target organ of a patient, comprising:
- a) a catheter comprising a proximal end, distal end, an inner lumen extending between the proximal and distal ends, and an exterior surface;
- b) an expandable vessel occluder coupled to a distal portion of the exterior surface, the occluder movable between an expanded configuration adapted to block reflux of the therapeutic agent in the primary vessel or the feeder vessel, and a collapsed configuration having a diameter smaller than a diameter of the expanded configuration;
- c) a pressure detecting element positioned proximal of the expandable vessel occluder and in fluid communication with the distal end of the catheter through the inner lumen when the expandable vessel occluder is in the expanded configuration, the pressure detecting element configured to continuously sense a vessel pressure distal of the occluder;
- d) an infusion system configured to infuse the therapeutic agent through the inner lumen of the catheter and into the feeder vessel at a rate of infusion, wherein the rate of infusion is dynamically adjusted based on the vessel pressure detected by the pressure detecting element to maintain an intended pressure value during infusion;
- and
- e) a timing system operably connected to the infusion system, and configured to determine whether a change in pressure correlated to a cycle of a heart rate of the patient has been detected in the pressure sensed by the pressure detecting element, and to delay activation of the infusion system by a set time offset to a time in the cycle of the heart rate that increases pressure differential in the target organ during infusion when the change in pressure is detected.
3 more elements
A system for infusing a therapeutic agent through a primary vessel and into a feeder vessel in a target organ of a patient, comprising:
- a) a catheter comprising a proximal end, distal end, an inner lumen extending between the proximal and distal ends, and an exterior surface;
- b) an expandable vessel occluder coupled to a distal portion of the exterior surface, the occluder movable between an expanded configuration adapted to block reflux of the therapeutic agent in the primary vessel or the feeder vessel, and a collapsed configuration having a diameter smaller than a diameter of the expanded configuration;
- c) a sensor system configured to continuously monitor vital signs of the patient correlating to a pulse of the patient;
- d) an infusion system configured to infuse the therapeutic agent through the inner lumen of the catheter and into the feeder vessel;
- and
- e) a timing system operably connected to the sensor system and the infusion system, the timing system configured to determine whether a timing condition within the pulse of the patient is detected in the vital signs monitored by the sensor system, and to delay activation of the infusion system by a set time offset that increases pressure differential in the target organ during infusion when the timing condition is detected.
3 more elements
Dependencies are inferred from the claim text.