Chimeric peptide-modified SIS membrane, preparation method therefor and application thereof
AssigneeBeijing Biosis Healing Biological Technology Co., Ltd.
InventorsPengfei Wei, Huasheng Wang, Bo Zhao
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Abstract
A chimeric peptide-modified SIS membrane, a preparation method therefor and an application thereof. The chimeric peptide-modified SIS membrane is used to promote the expression of ITG-α3, ITG-β1, BMP2, RUNX2, ALP and OPN, and inhibits the growth of Streptococcus gordonii and Streptococcus sanguinis, thereby enabling the SIS membrane to exert antibacterial, osteogenic and healing-promoting biological functions. The SIS membrane (that is, a chimeric peptide-modified GBR film) can be used for clinical treatment of infectious bone defects.
Claims15
A chimeric peptide-modified SIS membrane, wherein the sequence of the chimeric peptide comprises at least one sequence in a group consisting of sequences shown as follows:
- (i) a group consisting of a sequence as set forth in SEQ ID NO:
- 9, a sequence as set forth in SEQ ID NO:
- 10, a sequence as set forth in SEQ ID NO:
- 11, and a sequence as set forth in SEQ ID NO:
- 12;
- and
- (ii) a sequence with a conservative substitution as compared to the sequence set forth in (i).
A method for preparing a chimeric peptide-modified SIS membrane, wherein the method comprises the following steps:
- (a) dissolving the chimeric peptide into a solvent to obtain a solution containing the chimeric peptide;
- (b) applying the solution obtained in step (a) to the surface of the SIS membrane;
- and
- (c) drying the SIS membrane with the solution on the surface thereof to obtain the chimeric peptide-modified SIS membrane;
- wherein the sequence of the chimeric peptide comprises or consists of at least one in a group consisting of sequences shown as follow:
- (i) a group consisting of a sequence as set forth in SEQ ID NO:
- 9, a sequence as set forth in SEQ ID NO:
- 10, a sequence as set forth in SEQ ID NO:
- 11, and a sequence as set forth in SEQ ID NO:
- 12;
- and
- (ii) a sequence with a conservative substitution as compared to the sequence set forth in (i).
Dependencies are inferred from the claim text.