Fiber membrane and preparation method and use thereof

A preparation method of a fiber membrane, the fiber membrane comprising a fiber with a core-shell structure, wherein a core of the fiber comprises simvastatin and a first spinnable polymer, and a shell of the fiber comprises hydroxyapatite and a second spinnable polymer, the method comprising the following steps:

• conducting coaxial electrospinning on a core spinning solution and a shell spinning solution to obtain the fiber membrane;
• wherein
• the core spinning solution comprises the simvastatin and the first spinnable polymer;
• the shell spinning solution comprises the hydroxyapatite and the second spinnable polymer,
• the first spinnable polymer and the second spinnable polymer each are polycaprolactone,
• wherein the core spinning solution comprises 5 g/L to 20 g/L of the simvastatin and 100 g/L to 150 g/L of the first spinnable polymer by concentration;
• the coaxial electrospinning is conducted at a voltage of 7.5 kV to 8.5 kV with a spinning nozzle and a collector spaced apart by 15 cm;
• the core spinning solution is added at a flow rate of 1.5 mL/h, and the shell spinning solution is added at a flow rate of 1.0 mL/h;
• and
• the core spinning solution comprises an organic solvent including hexafluoroisopropanol, wherein the core spinning solution is prepared by mixing the simvastatin, the first spinnable polymer, and the organic solvent.