Immunostimulatory toll-like receptor agonist-nanoparticle for cancer immunotherapy
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsQian Yin, Mark M. Davis
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Abstract
Compositions and methods are provided relating to immunostimulatory TLR agonist nanoparticle formulations. Methods are provided for treating cancer, by stimulating an immune response to cancer cells through administering to an individual mammal an effective dose or series of doses of an immunostimulatory composition comprising an immunostimulatory TLR agonist-nanoparticle; optionally in combination with a second immune regulatory agent.
Claims18
An immunostimulatory nanoparticle comprising:
- a TLR agonist conjugated to a first polymer through a cleavable linkage, precipitated into a nanoparticle;
- wherein the first polymer is poly-lactic acid comprising from about 5% to about 25% by weight the TLR agonist.
A method of generating a polymer comprising a plurality of ester linked TLR agonist moieties, the method comprising:
- initiating a ring-opening polymerization (ROP) reaction of lactide with the TLR agonist as the initiator, to generate a polymer comprising a defined level of TLR agonist loading, wherein the TLR agonist is optionally gardiquimod, wherein the polymer comprises from about 5% to about 25% by weight the TLR agonist.
Dependencies are inferred from the claim text.