Anti-HER2 immunoconjugates, and uses thereof
AssigneeBolt Biotherapeutics, Inc.
InventorsShelley Erin Ackerman, Michael N. Alonso, Romas Kudirka, Arthur Lee, Brian Safina, Matthew Zhou
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Abstract
The invention provides immunoconjugates of Formula I comprising an anti-HER2 antibody linked by conjugation to one or more 8-Het-2-aminobenzazepine derivatives. The invention also provides 8-Het-2-aminobenzazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.
Claims4
An 8-Het-2-aminobenzazepine-linker compound of formula:
An immunoconjugate comprising an antibody covalently attached to one or more 8-Het-2-aminobenzazepine moieties by a linker, and having formula:
- or a pharmaceutically acceptable salt thereof, wherein Ab is an antibody and p is an integer from 1 to 8.
Dependencies are inferred from the claim text.