Modulating permeability of the blood cerebrospinal fluid barrier
AssigneeMemorial Sloan Kettering Cancer Center
InventorsAdrienne Boire, Joan Massague
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Abstract
The present invention relates to methods and compositions for modulating the blood CSF barrier and for diagnosing, preventing and/or treating leptomeningeal metastasis. In particular embodiments of the invention, the permeability of the blood CSF barrier is modulated by agonists or antagonists of Complement Component 3 (C3) or its receptor.
Claims20
A method of treating a subject suffering from a disorder of the central nervous system, comprising administering (i) an effective amount of an agonist of C3 or C3aR and (ii) an effective amount of a second therapeutic agent, wherein the second therapeutic agent is selected from the group consisting of an antimicrobial agent, an antibacterial agent, an antiviral agent, an antifungal agent, an antiprotozoal agent, an antiparasitic agent, an anthelmintic agent and an anticancer agent.
A method of treating a subject suffering from a disorder of the central nervous system, consisting of administering (i) an effective amount of an agonist of C3 or C3aR and (ii) an effective amount of a second therapeutic agent, wherein the second therapeutic agent is selected from the group consisting of an antimicrobial agent, an antibacterial agent, an antiviral agent, an antifungal agent, an antiprotozoal agent, an antiparasitic agent, an anthelmintic agent and an anticancer agent.
Dependencies are inferred from the claim text.