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US 12,678,490 B2Granted
Pharmaceutical combinations comprising insulin and at least an agent selected from meloxicam, bromfenac sodium, acetylsalicylic acid, salicyclic acid and paracetamol
AssigneeEli Lilly and Company
InventorsJohn Michael Beals, Eric Dwayne Hawkins, Anthony Shane Ransdell, Shantanu Virendra Sule, Monica Rixman Swinney
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Abstract
The present invention relates to pharmaceutical insulin compositions comprising insulin, a preservative, and at least one selected from the group consisting of aspirin, acetaminophen, dexamethasone, heparin, meloxicam, bromfenac sodium, salicylic acid; and the use of the compositions to treat diabetes.
Claims1
A method of treating diabetes comprising administering to a human in need thereof an effective dose of a pharmaceutical composition comprising:
- (a) rapid acting insulin or ultra-rapid acting insulin;
- (b) m-cresol;
- and
- (c) meloxicam,
- wherein the insulin concentration is from about 100 U/mL to about 500 U/mL, the concentration of m-cresol is from about 2.5 mg/mL to about 3.8 mg/mL, and the concentration of meloxicam is from about 0.015 mg/ml to about 5.0 mg/mL.
2 more elements
Dependencies are inferred from the claim text.