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US 12,678,481 B2Granted
Gla domains as therapeutic agents
AssigneeGladiator Biosciences, Inc.
InventorsMaxine Bauzon, Terry Hermiston
Life of this patent
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Abstract
The disclosure relates to the recombinant Gla domain proteins and their use targeting phosphatidylserine (PtdS) moieties on the surface of cells, particularly those expressing elevated levels of PtdS, such as cells undergoing apoptosis.
Claims10
A diagnostic probe molecule for detection of apoptosis by targeting phosphatidylserine cell-surface expression in vivo, said probe molecule comprising:
- a polypeptide comprising a protein S gamma-carboxyglutamic-acid (Gla) domain and a protein S Epidermal Growth Factor (EGF) domain, and wherein the polypeptide is fused to a proteinaceous sequence comprising a detectable label or a proteinaceous sequence conjugated to a detectable label;
- wherein said probe molecule does not contain a serine protease domain from a Gla domain protein and also does not contain a hormone-binding domain from a Gla domain protein;
- and
- wherein said polypeptide comprises SEQ ID NO:
- 6 or a derivative differing therefrom only in the absence of the His-tag.
2 more elements
Dependencies are inferred from the claim text.