Method to improve therapeutic properties of stem cells
AssigneeAtomic Energy of Canada Limited/éNergie Atomique Du Canada LimitéE
InventorsDmitry Klokov, Soji Sebastian, Yevgeniya Le
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Abstract
In one aspect, a method of preconditioning stem cells comprising exposing stem cells to low dose radiation (LDR) is provided. In another aspect, a population of preconditioned stem cells is provided, wherein the population of 5 preconditioned stem cells is obtained by exposing stem cells to LDR. Uses of the preconditioned stem cells are also provided. In other aspects, the stem cells are muscle stem cells.
Claims18
A population of preconditioned muscle stem cells, wherein the population of preconditioned muscle stem cells is obtained by using a method of preconditioning muscle stem cells, the method comprising:
- a. providing a sample comprising a plurality of target muscle stem cells;
- b. irradiating the target muscle stem cells with a low dose of radiation comprising between 10 and 100 mGy of radiation emitted from a radiation source during an irradiation period to convert the target muscle stem cells to irradiated, preconditioned muscle stem cells suitable for use in a subsequent therapeutic treatment process;
- wherein irradiating the target muscle stem cells reduces age-associated decline of at least a first cellular function of each target muscle stem cell.
Dependencies are inferred from the claim text.