Extracellular vesicles and compositions thereof
AssigneeExo Biologics SA
InventorMarcin Jurga
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Abstract
The current invention relates to a composition comprising extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs). The EVs are part of a population of particles in the composition having a particle size of between 0.05 and 0.22 micron. The concentration of these particles is at least 1×1011 particles per ml of composition. At least 90% of the particles with particle size of between 0.05 and 0.22 micron are EVs. The EVs are defined by having a concentration of intra-vesicular Annexin V of at least 40 ng/ml and a concentration of extra-vesicular Annexin V of less than 1 ng/ml. Uses of the composition also are disclosed.
Claims12
A pharmaceutical composition comprising Extracellular Vesicles (EVs) derived from Mesenchymal Stromal Cells (MSCs), wherein said particles have a particle size of between 0.05 and 0.22 micron, wherein at least 90% of said particles with a particle size of between 0.05 and 0.22 micron are said EVs, wherein said EVs are associated with Annexin V and human albumin, and wherein said composition comprises said EVs at a ratio of between 5 and 222 μg said EVs associated with Annexin V per g EVs associated with human albumin.
Dependencies are inferred from the claim text.