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US 12,678,456 B1Granted
Photothermal-responsive injectable hydrogel for wound healing, healing, antibacterial and other biomedical applications
AssigneeThe Florida International University Board of Trustees
InventorsCheng-Yu Lai, Daniela Rodica Radu
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Abstract
The subject invention provides a novel class of mixed-metal chalcogenide compounds exhibiting POD-like catalytic activity, efficient photothermal conversion under NIR irradiation, and broad-spectrum antimicrobial properties. The invention further provides hydrogel formulations incorporating these compounds in a polymeric matrix, as well as their use in a range of biomedical applications, such as treating infected wounds, preventing surgical site infections, and delivering localized, non-antibiotic antimicrobial therapy.
Claims13
A hydrogel formulation comprising:
- (i) a mixed-metal chalcogenide having a general formula of MxM′1-xXy, wherein M and M′ are distinct transition metal elements, and X is a chalcogen element;
- and wherein 0≤x≤1 and 1.5≤y≤2.5;
- (ii) a thermo-responsive polymer;
- and (iii) a matrix polymer.
1 more element
Dependencies are inferred from the claim text.